Endocrine Abstracts

Introduction: Total thyroidectomy (TT) is a safe and effective operation. The most frequent complication after TT is hypoparathyroidism. Surgical trauma, devasculisation of parathyroid glands and inadvertent parathyroidectomy have been identified as the main causes resulting in postoperative hypocalcaemia. The objectives of this study are to investigate the incidence of intrathyroid parathyroid glands (ITPGs) in a large cohort and to clarify their histological characteristics....

Introduction: Inflammatory bowel disease (IBD) has been associated with various disorders of thyroid function. Many of these patients are now treated with biological agents targeting on TNF-a.Aim: To investigate thyroid function in patients with IBD and the potential effect of anti-TNF therapy.Patients and methods: We studied 41 patients with IBD (25M/16F, 36.4±11 years), without any known thyroid disorder. Eighteen patients (...

Introduction: Medullary thyroid carcinoma (MTC) originated from parafollicular C cells of the thyroid gland is a rare histological type of malignancy. Common sites of metastases are liver, lungs and bones, while metastases in other sites are extremely rare. Breast metastases from MTC are reported in 20 cases, and only in women.Case report: A 67-year-old man was presented after thyroidectomy for further evaluation and treatment. Histology was positive for...

Introduction: Giant prolactinomas are rare pituitary tumours. They can present with visual field defect, intracranial pressure symptoms and even temporal lobe epilepsy. Impairment of higher cognitive functions has been reported postoperatively after trans-cranial surgery and following radiotherapy. Reversible cognitive disturbances have been previously reported in patients with surgically decompressed arachnoid cysts but not after medical treatment of giant prolactinoma. We pr...

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

Introduction: The aim of the present study was to evaluate if demographic and histological characteristics as well as the long-term outcome of thyroid cancer was different in children and adolescents with and without autoimmune thyroiditis taking into consideration that information in the literature is scarce.Methods: The medical records of children and adolescents (≤21-year-old) followed up in Theagenio Cancer Hospital due to histologically proven...

Introduction: The molecular pathogenesis of pancreatic neuroendocrineneoplasms (PNEN) is increasingly yet incompletely understood. PNEN typically occur sporadically or may occur within the context of hereditary tumor predisposition syndromes. PNEN can also be associated with endocrinopathy of hormonal hypersecretion. We present a young male with a multi-hormonal neuroendocrine neoplasm of pancreas.Case presentation: A 24-year-old male, non-smok...

Introduction: Some endocrine disorders, including hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency, are caused by an autoimmune response to endocrine organs. Previous data have also shown that isolated ACTH deficiency may be associated at least in part with a paraneoplastic syndrome. We present a rare case with isolated ACTH deficiency along with ectopic posterior hypophysis.Case presentation: A 53-yea...

Introduction: Denosumab is a new pharmacotherapy option for postmenopausal osteoporosis. It is a human monoclonal antibody against RANKL, acting as an osteoprotegerin (OPG) analog. Recently, osteoprotegerin levels were found to be elevated in type two diabetes while insulin resistance was shown to be positively associated with decreased serum OPG levels, in healthy obese subjects. However, no study has been conducted in order to clarify the effect of anti-RANKL factors adminis...

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...